April 22, 2015

Mesenchymal stem cells, which are found in umbilical cord blood, contain immune modulatory properties. These properties were used to treat collagen-induced arthritis in a recent clinical trial to determine the effectiveness of stem cells collected from cord blood banking, in treating this type of arthritis. Treatment-control mice were injected with 35 mg/kg methotrexate twice weekly, with mesenchymal stem cells taken from cord blood, bone marrow, and adipose tissue. Over the study period, the mice were evaluated. Cytokine expression in the join, serum cytokine levels, degree of inflammation, and regulatory T cells were all observed and evaluated. This process on some level answers the question, “What is stem cell research?” (which we know many people who are new to cord blood banking are asking themselves).

Mice treated with mesenchymal stem cells, which were derived from umbilical cord blood, showed significant improvement in clinical joint score. Histologic examination results showed that joint damage and inflammation was greatly reduced in mice treated with mesenchymal stem cells, versus untreated mice. Joint inflammation overall was significantly suppressed. The cells decreased pro-inflammatory cytokines and upregulated anti-inflammatory cytokines and induced Tregs.

In short, this clinical trial study shows that human cord blood mesenchymal stem cells could potentially be an effective therapeutic approach for treating collagen-induced arthritis. This is why private cord blood banking with CariCord is a viable option to consider during your stages of pregnancy. Cord blood stem cells can be stored in a bank until needed, and can be used to treat a variety of diseases, including arthritis, various types of cancers, leukemia. They are also used for anemia treatment, and more than 80 diseases in all, with more stem cell research revealing new diseases that cord blood can be used to treat.

Those familiar with umbilical cord blood banking know that cord blood, that produces mesenchymal stem cells, can only be collected at the birth of a child, not in early pregnancy stages or after birth. This is why it is important to consider your public and private cord blood banking options during your earlier stages of pregnancy, so that you can make an informed decision of what to do with your child’s cord blood, which could possibly be used in an anemia treatment for your child or a suitable match at some point down the road.

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April 20, 2015

A recent cord blood study (livepage.apple.com) found that cells which had been cryopreserved for 8 years were still as viable as freshly collected cord blood cells from the birth of a child after a mother went through the various stages of pregnancy and gave birth. Because successful hematopoietic stem cell transplantation (using cord blood units stored in a bank) depends largely on the quality of the cells, it is crucial that preserved cord blood is equally viable to freshly collected cord blood.

This umbilical cord blood banking study involved the analysis of 60 units of cord blood, which had been cryopreserved for 8 years in one particular public cord blood bank where recent mothers store their newborn’s cells after going through the various pregnancy stages and giving birth. A flow cytometry method was used to determine the viability of the cells after they were thawed, and the study showed that the viability of the preserved cells was nearly identical to fresh umbilical cord blood cells, 48 hour after collection.

If you are new to umbilical cord blood banking or just asking yourself, “What is stem cell research?”, it will be comforting to know that the process not only potentially cures more than 80 diseases (many of which are life-altering or threatening), but that the preserved cells maintain their viability even after they have been stored in a secure facility (like the one CariCord uses) for nearly a decade. No matter where you are in your stages of pregnancy, you should know that private cord blood banking through CariCord is an excellent step towards securing your child’s future health, and scientific stem cell research proves it!

Currently, the stem cells found in umbilical cord blood can be used for anemia treatment, cancer treatment, leukemia treatment, and many more ailments; more than 80 in all. The decision to store your child’s cord blood is one that must be made before you complete your final pregnancy stages and give birth, as the cord blood stem cells from your child’s cord blood can only be collected, stored, and preserved at birth.

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April 17, 2015

When it comes to umbilical cord blood banking, many people ask the question, “How are cells taken from cord blood different from other types of stem cells?” Well, there any many things that newborn and adult stem cells have in common, there are also many differences. Both are able to differentiate to form various types of cells and are proven successful in treating people for diseases, but the primary difference is that newborn stem cells (found in cord blood) are biologically younger than adult stem cells taken from sources such as bone marrow. This means that newborn cells saved through umbilical cord blood banking are more flexible and therefore have more treatment possibilities than adult stem cells. For those unfamiliar with stem cell research, both of these types of cells are different from the embryonic stem cells you may have heard about, so collecting and using them for cancer, leukemia, or anemia treatment is not unethical or controversial.

In the early or later stages of pregnancy, an expecting mother can opt for private cord blood banking through CariCord, which stores her newborn’s cord blood stem cells in a private bank for personal use, in the event that they are ever needed. In the event that a cell transplant becomes necessary, these “newborn” adult stem cells carry less risk of complications than adult stem cells. Because they were stored in a private bank, they are readily available for immediate treatment, which can stop the progression of a disease earlier. This is not always an option with other types of stem cells, as you may have to wait for them to become available, to use them in a cancer or anemia treatment.

Another factor that makes cord blood stem cells unique is they are collected at the birth of a child, so they are not exposed to common viruses and environmental factors that is often the case with adult stem cells. This can make them more effective in treatments, and increase the usability of the cells in performing a specific treatment.

Expecting mothers in the earlier pregnancy stages should research the options for saving or donating their child’s cells to a private or public cord blood bank. That way, you can make an informed decision in the later stages of pregnancy, to ensure that your child’s cord blood cells are potentially utilized rather than discarded at birth. You never know whether or not your child’s cord blood will save a life, so it is good to consider donating it to a public bank if you opt not to store it for future personal use.

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April 15, 2015

Hodgkin lymphoma, more commonly known as Hodgkin’s disease is a type of lymphoma where cancer originates from white blood cells. Current treatment options include chemotherapy, radiation, and hematopoietic stem cell transplantation. As you may already know, hematopoietic stem cells are commonly found in umbilical cord blood and carry the ability to self-renew. They are developed throughout the stages of pregnancy and can only be collected at the birth of a child, which is why it is a good idea to consider umbilical cord blood banking, no matter what pregnancy stage you are in.

A recent study reported the outcomes of 30 consecutive Hodgkin’s patients who went through the process of singular unit umbilical cord blood transplantation. The vast majority of these patients had failed previous autologous hematopoietic stem cell transplantation efforts. Some of these patient’s lives were saved as a result of this umbilical cord blood cell transplant. 26% of the patients who passed away were affected by post-transplant lymphoproliferative disease. Continued stem cell research should target this occurrence, so that in the future, cord blood stem cells can be more effective used to treat Hodgkin’s disease.

Despite the higher than expected mortality rate, the study reported that umbilical cord blood transplantation in heavily pre-treated Hodgkin’s patients is still a viable option, especially when there is a lack of a suitable adult stem cell donor. This is one of the reasons why umbilical cord blood banking should be considered during the stages of pregnancy. When you save your child’s cord blood stem cells at CariCord’s safe and secure private family bank, you can rest assured that they will be available in the event that they are ever needed, without having to wait for a potential donor that may never come about. While stem cell research still has much progress to be made in the treatment of Hodgkin’s disease, cord blood is currently used to treat more than 80 diseases, including various cancers and lymphomas, as well as anemia treatment. The decision to bank your child’s cord blood can be made during any of the stages of pregnancy.

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